Szczegóły obiektu: Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts

Instytucja dostarczająca:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Opis

Tytuł:
Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts
Twórca:
Liberek, Anna;
Kmieć, Zbigniew;
Wierzbicki, Piotr;
Jakóbkiewicz-Banecka, Joanna;
Liberek, Tomasz;
Łuczak, Grażyna;
Plata-Nazar, Katarzyna;
Słomińska-Frączek, Magdalena;
Kaszubowska, Lucyna;
Gabig-Cimińska, Magdalena;
Węgrzyn, Alicja
Opis:
Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.
Dostępność obiektu:
Dostęp otwarty
Data:
2013
Typ:
Article;
PeerReviewed
Język:
angielski
Format:
application/pdf
Relacja: http://eprints.ibb.waw.pl/1125
Temat i słowa kluczowe:
Q Science (General);
R Medicine (General)
Identyfikator: http://eprints.ibb.waw.pl/1125/1/Paper_ABP_2013.pdf ;
Liberek, Anna and Kmieć, Zbigniew and Wierzbicki, Piotr and Jakóbkiewicz-Banecka, Joanna and Liberek, Tomasz and Łuczak, Grażyna and Plata-Nazar, Katarzyna and Słomińska-Frączek, Magdalena and Kaszubowska, Lucyna and Gabig-Cimińska, Magdalena and Węgrzyn, Alicja (2013) Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts. Acta Biochimica Polonica, 60 . pp. 683-688.
Dostawca danych:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Szczegóły obiektu: Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts

Opis

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