Opis

• Tytuł:
  Anticancer agents found in environment affect Daphnia at population, individual and molecular levels
• Twórca:
  Grzesiuk, Małgorzata;
  Bednarska, Anna;
  Mielecki, Damian;
  Garbicz, Damian;
  Marcinkowski, Michał;
  Pilżys, Tomasz;
  Malinowska, Agata;
  Świderska, Bianka;
  Grzesiuk, Elzbieta
• Opis:
  Pharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization diseases, such as different type of cancer, significantly contribute to this form of pollution. The aim of the present study was to determine how the exposure to chemotherapeutics: cyclophosphamide (CP) and cisplatin (CDDP), at detected in environment concentrations, influence proteome profile, life history and population parameters of naturally setting surface waters Daphnia pulex and Daphnia pulicaria. The parameters important for crustaceans, survivorship and population growth rate, were importantly decreased by CDDP treatment but not influenced by CP. On the contrary, the individual growth rate was affected only by CP and exclusively in the case of D. pulicaria. In both clones treated with CP or CDDP, decreased number of eggs was observed. Interestingly, Daphnia males were less sensitive to tested chemotherapeutic than females. Proteome profile revealed that tested anticancer pharmaceuticals modified expression of some proteins involved in Daphnia metabolism. Moreover, males exposed to CDDP showed increased level of enzymes participating in DNA repair. Summing up, the contaminating environment chemotherapeutics reduced fitness of naturally occurring Daphnia species. In consequence this may affect functioning of the aquatic food webs.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2019.08.30
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  application/msword
• Wydawca:
  Elsevier
• Relacja: http://eprints.ibb.waw.pl/1757 ;https://www.sciencedirect.com/science/article/abs/pii/S0166445X19304059 ;https://doi.org/10.1016/j.aquatox.2019.105288
• Temat i słowa kluczowe:
  GE Environmental Sciences;
  QL Zoology;
  QP Physiology;
  QR Microbiology;
  RM Therapeutics. Pharmacology
• Identyfikator: http://eprints.ibb.waw.pl/1757/1/2019-08-27_Aquatic_Toxicol_rep.doc ;
  Grzesiuk, Małgorzata and Bednarska, Anna and Mielecki, Damian and Garbicz, Damian and Marcinkowski, Michał and Pilżys, Tomasz and Malinowska, Agata and Świderska, Bianka and Grzesiuk, Elzbieta (2019) Anticancer agents found in environment affect Daphnia at population, individual and molecular levels. Aquatic Toxicology, 215 (105288). p. 105288. ISSN 0166-445X
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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