Szczegóły obiektu: Streptococcus anginosus orchestrates antibacterial potential of NETs facilitating survival of accompanying pathogens

Instytucja dostarczająca:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Opis

Title:
Streptococcus anginosus orchestrates antibacterial potential of NETs facilitating survival of accompanying pathogens
Creator:
Pilarczyk-Zurek, Magdalena;
Budziaszek, Joanna;
Nandagopal, Keerthanaa;
Kuryłek, Aleksandra;
Kozińska, Aleksandra;
Dmowski, Michal;
Sitkiewicz, Izabela;
Kern-Zdanowicz, Izabela;
Kozieł, Joanna;
Kern-Zdanowicz, I.
Description:
Streptococcus anginosus is considered an emerging opportunistic pathogen causing life-threatening infections, including abscesses and empyema. Noticeably, clinical data revealed that S. anginosus also constitutes an important component of polymicrobial infections. Here, we showed for the first time that S. anginosus inactivates the antibacterial potential of neutrophil extracellular traps (NETs). The process is determined by a cell wall-anchored nuclease referred to as SanA, which high expression dominates in clinical strains isolated from severe infections. Nuclease activity protects S. anginosus against the antibacterial activity of NETs, supporting at the same time the survival of coexisting highly pathogenic species of Enterobacteriales. Obtained data suggest that SanA nuclease should be recognized as a critical S. anginosus virulence factor determining severe monospecies purulent infections but also shielding other pathogens promoting the development of polymicrobial infections.
Object availability:
Dostęp otwarty
Date:
2025
Type:
Article;
PeerReviewed
Language:
angielski
Format:
application/pdf;
application/zip
Publisher:
Elsevier
Relation: http://eprints.ibb.waw.pl/2471 ;https://www.sciencedirect.com/journal/microbiological-research ;https://doi.org/10.1016/j.micres.2024.127959
Subject:
QR Microbiology;
QR180 Immunology
Identifier: http://eprints.ibb.waw.pl/2471/1/1-s2.0-S0944501324003604-main.pdf ;http://eprints.ibb.waw.pl/2471/7/ScienceDirect_files_07Nov2024_15-00-35.951.zip ;
Pilarczyk-Zurek, Magdalena and Budziaszek, Joanna and Nandagopal, Keerthanaa and Kuryłek, Aleksandra and Kozińska, Aleksandra and Dmowski, Michal and Sitkiewicz, Izabela and Kern-Zdanowicz, Izabela and Kozieł, Joanna and Sitkiewicz, Izabela and Kern-Zdanowicz, I. (2025) Streptococcus anginosus orchestrates antibacterial potential of NETs facilitating survival of accompanying pathogens. Microbiological Research, 290 (127959). 02-106. ISSN 0944-5013
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Szczegóły obiektu: Streptococcus anginosus orchestrates antibacterial potential of NETs facilitating survival of accompanying pathogens

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