Opis

• Tytuł:
  Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients
• Twórca:
  Ambroziak, Urszula;
  Kuryłowicz, Alina;
  Kępczyńska-Nyk, Anna;
  Bartoszewicz, Zbigniew;
  Kondracka, Agnieszka;
  Jazwiec, Radoslaw;
  Samborowska, Emilia;
  Dadlez, Michal;
  Wysłouch-Cieszyńska, Aleksandra;
  Bednarczuk, Tomasz
• Opis:
  Objectives: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. Material and methods: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism. In all participants, anthropometric data, lipids, adipose tissue percent (%fat), HOMA-IR were also assessed. Results: The studied groups were not different in terms of age, BMI, waist circumference, %fat and HOMA-IR. In the patients group, mean TT and androstendione levels were significantly higher as compared to controls (1.4 nmol/L vs. 1.0 nmol/L, P < 0.001) and (6.6 nmol/L vs. 4.9 nmol/L, P < 0.01), respectively. In the patients group, mean TT/DHT ratio was significantly higher compared to controls (3.6 vs. 2.7, P < 0.01) and correlated with BMI (r = 0.37, P < 0.05), waist circumference (r = 0.44, P < 0.01), %fat (r = 0.30, P < 0.05), as well as with insulin levels (r = 0.38, P < 0.05) and HOMA-IR (r = 0.44, P < 0.05). The association between TT/DHT ratio and unfavorable metabolic parameters was also seen in controls. Conclusion: Total testosterone/dihydrotestosterone ratio assessed by LC-MS/MS correlates with a worse metabolic profile not only in PCOS patients, but also in healthy women.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2017.01
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  application/pdf
• Relacja: http://eprints.ibb.waw.pl/1455 ;http://doi.org/10.5603/GP.a2017.0001 ;doi:10.5603/GP.a2017.0001
• Temat i słowa kluczowe:
  RG Gynecology and obstetrics
• Identyfikator: http://eprints.ibb.waw.pl/1455/1/47871-115724-1-PB.pdf ;
  Ambroziak, Urszula and Kuryłowicz, Alina and Kępczyńska-Nyk, Anna and Bartoszewicz, Zbigniew and Kondracka, Agnieszka and Jazwiec, Radoslaw and Samborowska, Emilia and Dadlez, Michal and Wysłouch-Cieszyńska, Aleksandra and Bednarczuk, Tomasz (2017) Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients. Ginekologia Polska, 88 (1). pp. 5-8. ISSN 0017-0011
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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