Opis

• Tytuł:
  Utilization of cobalamin is ubiquitous in early-branching fungal phyla
• Twórca:
  Orłowska, Małgorzata;
  Steczkiewicz, Kamil;
  Muszewska, Anna
• Opis:
  Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes. Cobalamin dependence is scattered across the tree of life. In particular, fungi and plants were deemed devoid of cobalamin. We demonstrate that cobalamin is utilized by all non-Dikarya fungi lineages. This observation is supported by the genomic presence of both B12-dependent enzymes and cobalamin modifying enzymes. Fungal cobalamin-dependent enzymes are highly similar to their animal homologs. Phylogenetic analyses support a scenario of vertical inheritance of the cobalamin usage with several losses. Cobalamin usage was probably lost in Mucorinae and at the base of Dikarya which groups most of the model organisms and which hindered B12-dependent metabolism discovery in fungi. Our results indicate that cobalamin dependence was a widely distributed trait at least in Opisthokonta, across diverse microbial eukaryotes and was likely present in the LECA.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2021
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  application/pdf
• Wydawca:
  Oxford
• Relacja: http://eprints.ibb.waw.pl/2006 ;http://doi.org/10.1093/gbe/evab043 ;doi:10.1093/gbe/evab043
• Temat i słowa kluczowe:
  QH301 Biology;
  QR Microbiology
• Identyfikator: http://eprints.ibb.waw.pl/2006/1/evab043.pdf ;
  Orłowska, Małgorzata and Steczkiewicz, Kamil and Muszewska, Anna (2021) Utilization of cobalamin is ubiquitous in early-branching fungal phyla. Genome Biology and Evolution, 13 (4). evab043. ISSN 1759-6653
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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