Opis

• Tytuł:
  Structure of the Head of the Bartonella Adhesin BadA
• Twórca:
  Szczesny, Pawel;
  Linke, Dirk;
  Ursinus, Astrid;
  Baer, Kerstin;
  Schwarz, Heinz;
  Riess, Tanja M.;
  Kempf, Volkhard A. J.;
  Lupas, Andrei;
  Martin, Joerg;
  Zeth, Kornelius
• Opis:
  Trimeric autotransporter adhesins (TAAs) are a major class of proteins by which pathogenic proteobacteria adhere to their hosts. Prominent examples include Yersinia YadA, Haemophilus Hia and Hsf, Moraxella UspA1 and A2, and Neisseria NadA. TAAs also occur in symbiotic and environmental species and presumably represent a general solution to the problem of adhesion in proteobacteria. The general structure of TAAs follows a head-stalk-anchor architecture, where the heads are the primary mediators of attachment and autoagglutination. In the major adhesin of Bartonella henselae, BadA, the head consists of three domains, the N-terminal of which shows strong sequence similarity to the head of Yersinia YadA. The two other domains were not recognizably similar to any protein of known structure. We therefore determined their crystal structure to a resolution of 1.1 Å. Both domains are β-prisms, the N-terminal one formed by interleaved, five-stranded β-meanders parallel to the trimer axis and the C-terminal one by five-stranded β-meanders orthogonal to the axis. Despite the absence of statistically significant sequence similarity, the two domains are structurally similar to domains from Haemophilus Hia, albeit in permuted order. Thus, the BadA head appears to be a chimera of domains seen in two other TAAs, YadA and Hia, highlighting the combinatorial evolutionary strategy taken by pathogens.
• Dostępność obiektu:
  Dostęp otwarty
• Prawa:
  cc_by
• Data:
  2008.08.08
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski;
  eng
• Format:
  application/pdf
• Wydawca:
  PLoS
• Relacja: http://eprints.ibb.waw.pl/2 ;http://www.plospathogens.org/article/info:doi%2F10.1371%2Fjournal.ppat.1000119
• Temat i słowa kluczowe:
  QH301 Biology
• Identyfikator: http://eprints.ibb.waw.pl/2/1/journal.ppat.1000119.pdf ;
  Szczesny, Pawel and Linke, Dirk and Ursinus, Astrid and Baer, Kerstin and Schwarz, Heinz and Riess, Tanja M. and Kempf, Volkhard A. J. and Lupas, Andrei and Martin, Joerg and Zeth, Kornelius (2008) Structure of the Head of the Bartonella Adhesin BadA. PLoS Pathogens .
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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