Opis

• Tytuł:
  ATP Synthase Diseases of Mitochondrial Genetic Origin
• Twórca:
  Dautant, A.;
  Meier, Thomas;
  Hahn, Alexander;
  Tribouillard-Tanvier, Déborah;
  di Rago, Jean-Paul;
  Kucharczyk, Roza
• Opis:
  Devastating human neuromuscular disorders have been associated to defects in the ATP synthase. This enzyme is found in the inner mitochondrial membrane and catalyzes the last step in oxidative phosphorylation, which provides aerobic eukaryotes with ATP. With the advent of structures of complete ATP synthases, and the availability of genetically approachable systems such as the yeast Saccharomyces cerevisiae, we can begin to understand these molecular machines and their associated defects at the molecular level. In this review, we describe what is known about the clinical syndromes induced by 58 different mutations found in the mitochondrial genes encoding membrane subunits 8 and a of ATP synthase, and evaluate their functional consequences with respect to recently described cryo-EM structures.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2018
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski;
  eng
• Format:
  application/pdf
• Relacja: http://eprints.ibb.waw.pl/1555 ;http://doi.org/10.3389/fphys.2018.00329 ;doi:10.3389/fphys.2018.00329
• Temat i słowa kluczowe:
  R Medicine (General);
  RB Pathology
• Identyfikator: http://eprints.ibb.waw.pl/1555/1/Dautant-Frontiers2018.pdf ;
  Dautant, A. and Meier, Thomas and Hahn, Alexander and Tribouillard-Tanvier, Déborah and di Rago, Jean-Paul and Kucharczyk, Roza (2018) ATP Synthase Diseases of Mitochondrial Genetic Origin. Frontiers in Physiology, 9 (329). ISSN 1664-042X
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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