Opis

• Tytuł:
  Co-regulation of translation in protein complexes
• Twórca:
  Siwiak, Marlena;
  Zielenkiewicz, Piotr
• Opis:
  Background Co-regulation of gene expression has been known for many years, and studied widely both globally and for individual genes. Nevertheless, most analyses concerned transcriptional control, which in case of physically interacting proteins and protein complex subunits may be of secondary importance. This research is the first quantitative analysis that provides global-scale evidence for translation co-regulation among associated proteins. Results By analyzing the results of our previous quantitative model of translation, we have demonstrated that protein production rates plus several other translational parameters, such as mRNA and protein abundance, or number of produced proteins from a gene, are well concerted between stable complex subunits and party hubs. This may be energetically favorable during synthesis of complex building blocks and ensure their accurate production in time. In contrast, for connections with regulatory particles and date hubs translational co-regulation is less visible, indicating that in these cases maintenance of accurate levels of interacting particles is not necessarily beneficial. Conclusions Similar results obtained for distantly related model organisms, Saccharomyces cerevisiae and Homo sapiens, suggest that the phenomenon of translational co-regulation applies to the variety of living organisms and concerns many complex constituents. This phenomenon was also observed among the set of functionally linked proteins from Escherichia coli operons. This leads to the conclusion that translational regulation of a protein should always be studied with respect to the expression of its primary interacting partners. Reviewers This article was reviewed by Sandor Pongor and Claus Wilke.
• Dostępność obiektu:
  Dostęp otwarty
• Prawa:
  cc_by
• Data:
  2015.04.25
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  text/html;
  application/pdf
• Wydawca:
  BioMed Central
• Relacja: http://eprints.ibb.waw.pl/1020 ;http://www.biologydirect.com/content/10/1/18 ;doi:10.1186/s13062-015-0048-7
• Temat i słowa kluczowe:
  Q Science (General)
• Identyfikator: http://eprints.ibb.waw.pl/1020/1/index.html ;http://eprints.ibb.waw.pl/1020/3/13062_2015_Article_48.pdf ;
  Siwiak, Marlena and Zielenkiewicz, Piotr (2015) Co-regulation of translation in protein complexes. Biology Direct, 10 (18).
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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