Description

• Title:
  The Aspergillus nidulans metZ gene encodes a transcription factor involved in regulation of sulfur metabolism in this fungus and other Eurotiales
• Creator:
  Piłsyk, Sebastian;
  Natorff, Renata;
  Sieńko, Marzena;
  Skoneczny, Marek;
  Paszewski, Andrzej;
  Brzywczy, Jerzy
• Description:
  In Aspergillus nidulans, expression of sulfur metabolism genes is activated by the MetR transcription factor containing a basic region and leucine zipper domain (bZIP). Here we identified and characterized MetZ, a new transcriptional regulator in Aspergillus nidulans and other Eurotiales. It contains a bZIP domain similar to the corresponding region in MetR and this similarity suggests that MetZ could potentially complement the MetR deficiency. The metR and metZ genes are interrupted by unusually long introns. Transcription of metZ, unlike that of metR, is controlled by the sulfur metabolite repression system (SMR) dependent on the MetR protein. Overexpression of metZ from a MetR-independent promoter in a metR background, activates transcription of genes encoding sulfate permease, homocysteine synthase and methionine permease, partially complementing the phenotype of the metR mutation. Thus, MetZ appears to be a second transcription factor involved in regulation of sulfur metabolism genes.
• Object availability:
  free access
• Date:
  2015
• Type:
  Article;
  PeerReviewed
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Springer Berlin Heidelberg
• Relation: http://eprints.ibb.waw.pl/820 ;http://www.springer.com/life+sciences/genetics+%26+genomics/journal/294 ;doi:10.1007/s00294-014-0459-5
• Subject:
  QH301 Biology;
  QH426 Genetics
• Identifier: http://eprints.ibb.waw.pl/820/1/metZ_all.pdf ;
  Piłsyk, Sebastian and Natorff, Renata and Sieńko, Marzena and Skoneczny, Marek and Paszewski, Andrzej and Brzywczy, Jerzy (2015) The Aspergillus nidulans metZ gene encodes a transcription factor involved in regulation of sulfur metabolism in this fungus and other Eurotiales. Current Genetics, 61 (2). pp. 115-125. ISSN 1432-0983
• Data provider:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
• Can I use it?:
  seek permission
• Type:
  other