Object's details: Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders.
Creator:
Moskot, Marta;
Bocheńska, Katarzyna;
Jakóbkiewicz-Banecka, Joanna;
Banecki, Bogdan;
Gabig-Cimińska, Magdalena
Description:
Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.
Object availability:
free access
Date:
2018
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
MDPI
Relation: http://eprints.ibb.waw.pl/1688 ;https://www.mdpi.com/1422-0067/19/1/247
Subject:
Q Science (General)
Identifier: http://eprints.ibb.waw.pl/1688/1/Paper_IJMS_2018.pdf ;
Moskot, Marta and Bocheńska, Katarzyna and Jakóbkiewicz-Banecka, Joanna and Banecki, Bogdan and Gabig-Cimińska, Magdalena (2018) Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders. International Journal of Molecular Sciences, 19 (1). ISSN 1422-0067
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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