Description

• Tytuł:
  Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems.
• Twórca:
  Siwaszek, A;
  Ukleja, M;
  Dziembowski, Andrzej
• Opis:
  The process of mRNA decay and surveillance is considered to be one of the main posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of stable, protein-coding transcripts is normally initiated by removal of the poly(A) tail followed by 5'-cap hydrolysis and degradation of the remaining mRNA body by Xrn1. Alternatively, the exosome complex degrades mRNA in the 3'>5'direction. The newly discovered uridinylation-dependent pathway, which is present in many different organisms, also seems to play a role in bulk mRNA degradation. Simultaneously, to avoid the synthesis of incorrect proteins, special cellular machinery is responsible for the removal of faulty transcripts via nonsense-mediated, no-go, non-stop or non-functional 18S rRNA decay. This review is focused on the major eukaryotic cytoplasmic mRNA degradation pathways showing many similarities and pointing out main differences between the main model-species: yeast, Drosophila, plants and mammals.
• Dostępność obiektu:
  free access
• Data:
  2014.10.31
• Typ:
  Article;
  PeerReviewed
• Język:
  English;
  eng
• Format:
  application/pdf
• Wydawca:
  Landes Bioscience
• Relacja: http://eprints.ibb.waw.pl/872 ;http://www.tandfonline.com/doi/abs/10.4161/rna.34406?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.VKJcW14AoI ;
  25483043
• Temat i słowa kluczowe:
  QH301 Biology
• Identyfikator: http://eprints.ibb.waw.pl/872/1/KRNB_A_977153.pdf ;
  Siwaszek, A and Ukleja, M and Dziembowski, Andrzej (2014) Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems. RNA Biology . ISSN 1099-0123 (In Press)
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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