Object's details: The Effect of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on Bone Mineral Density in Postmenopausal Women: A Multicenter, Randomized, Placebo-Controlled Study

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
The Effect of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on Bone Mineral Density in Postmenopausal Women: A Multicenter, Randomized, Placebo-Controlled Study
Creator:
Głogowska-Szeląg, Joanna;
Palka-Kisielowska, Ilona;
Porawska, Wiesława;
Bierła, Joanna B.;
Szczepankowska, Agnieszka K.;
Aleksandrzak-Piekarczyk, Tamara;
Cukrowska, Bożena
Description:
Objectives: modulation of gut microbiota by probiotics has been proposed as a target for intervention to reduce bone mineral density (BMD) loss in the postmenopausal period. This study aims to evaluate the effect of Lacticaseibacillus (L.) paracasei LPC100 and Lactiplantibacillus (L.) plantarum LP140 on BMD in postmenopausal women in a multicenter, randomized, double-blind, placebo-controlled trial. Methods: the primary outcome was the change in T-score of the lumbar spine measured by dual-energy X-ray absorptiometry assessed after twelve-month probiotic supplementation. Secondary outcomes included changes in serological markers of inflammation and calcium–phosphate metabolism, body mass index, gastrointestinal symptoms, and satisfaction with the intervention. Results: a decrease in T-score indicating the progressive bone demineralization reached a statistically significant difference in the placebo group (from mean values of 0.06 ± 1.04 to −0.28 ± 1.12, p = 0.041) but not in the probiotic group (0.19 ± 0.99 and −0.08 ± 1.05, respectively, p = 0.125) with a p-value = 0.089 between the groups. No significant differences were found in secondary outcomes with the exception of vitamin D concentration and a significant reduction in some gastrointestinal symptoms in the probiotic group. A significant decrease in vitamin D level was observed only in the placebo group (p = 0.014). Probiotics were safe and well tolerated. Conclusions: this study suggests that the oral administration of L. paracasei LPC100 and L. plantarum LP140 may be a viable strategy to prevent BMD loss and vitamin D deficiency in postmenopausal women, but further research is necessary to confirm clinical benefits and to know the mechanism of action [ClinicalTrial.gov NCT06375668].
Object availability:
free access
Date:
2024.10.08
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
MDPI
Relation: http://eprints.ibb.waw.pl/2459 ;http://doi.org/10.3390/jcm13195977 ;doi:10.3390/jcm13195977
Subject:
QR Microbiology
Identifier: http://eprints.ibb.waw.pl/2459/1/jcm-13-05977.pdf ;
Głogowska-Szeląg, Joanna and Palka-Kisielowska, Ilona and Porawska, Wiesława and Bierła, Joanna B. and Szczepankowska, Agnieszka K. and Aleksandrzak-Piekarczyk, Tamara and Cukrowska, Bożena (2024) The Effect of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on Bone Mineral Density in Postmenopausal Women: A Multicenter, Randomized, Placebo-Controlled Study. Journal of Clinical Medicine, 13 (19). p. 5977. ISSN 2077-0383
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Similar objects

The Effect of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on Bone Mineral Density in Postmenopausal Women: A Multicenter, Randomized, Placebo-Controlled Study

Date:2024.10.08

Type:other

Whole-genome sequencing and characterization of human fecal isolate Lacticaseibacillus casei LC130 from NORDBIOTIC collection

Creator:Szczepankowska, Agnieszka K. | Cukrowska, Bozena | Aleksandrzak-Piekarczyk, Tamara

Date:2024.08.13

Type:other

Whole-genome sequencing and characterization of human fecal isolate Lacticaseibacillus casei LC130 from NORDBIOTIC collection

Creator:Szczepankowska, Agnieszka K. | Cukrowska, Bozena | Aleksandrzak-Piekarczyk, Tamara

Date:2024

Type:other

Complete genome sequence of the probiotic Lacticaseibacillus paracasei LPC100 strain from the NORDBIOTIC collection isolated from a human fecal sample

Creator:Szczepankowska, Agnieszka K. | Cukrowska, Bożena | Aleksandrzak-Piekarczyk, Tamara

Date:2024.08

Type:other

Lactose and β-Glucosides Metabolism and Its Regulation in Lactococcus lactis: A Review.

Creator:Aleksandrzak-Piekarczyk, Tamara

Date:2013.01

Type:text

The Lactococcal dgkB (yecE) and dxsA Genes for Lipid Metabolism Are Involved in the Resistance to Cell Envelope-Acting Antimicrobials

Creator:Tymoszewska, Aleksandra | Aleksandrzak-Piekarczyk, Tamara

Date:2021

Type:other

Badania nad mechanizmami działania i rozwoju oporności na bakteriocyny klasy II u bakterii Gram-dodatnich

Creator:Tymoszewska, Aleksandra | Aleksandrzak-Piekarczyk, Tamara

Date:2024.07.01

Type:other

GlaR (YugA)-a novel RpiR-family transcription activator of the Leloir pathway of galactose utilization in Lactococcus lactis IL1403

Creator:Aleksandrzak-Piekarczyk, Tamara | Szatraj, Katarzyna | Kosiorek, Katarzyna

Date:2019

Type:other

Federacja Bibliotek Cyfrowych

Object's details: The Effect of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on Bone Mineral Density in Postmenopausal Women: A Multicenter, Randomized, Placebo-Controlled Study

Description

Similar objects