Description

• Title:
  Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy
• Creator:
  Korzon-Burakowska, Anna;
  Jakóbkiewicz-Banecka, Joanna;
  Fiedosiuk, Aleksandra;
  Petrova, Nina;
  Koblik, Teresa;
  Gabig-Cimińska, Magdalena;
  Edmonds, Michael;
  Małecki, Maciej;
  Węgrzyn, Grzegorz
• Description:
  Aims: Recently, an association between two polymorphisms (1181G>C and 245T>G) of the osteoprotegerin (OPG) gene and diabetic Charcot neuroarthropathy was suggested on the basis of studies of a limited number of samples derived from subjects from one geographical region (Italy). The aim of this study was to assess the presence of various osteoprotegerin gene polymorphisms in patients with diabetes and Charcot neuroarthropathy compared with subjects with diabetic neuropathy but no Charcot foot and healthy controls from another geographical region (Poland). Methods: DNA was isolated from 54 patients with Charcot neuroarthropathy, 35 subjects with diabetic neuropathy but no Charcot foot, and 95 healthy controls to evaluateOPGgene polymorphisms and their possible contribution to the development of Charcot neuroarthropathy. Results: Statistically significant differences between the group of subjects with neuropathy but no Charcot neuroarthropathy and the control group were found for 1217C>T, 950T>C and 245T>G polymorphisms, between the group of patients with Charcot neuroarthropathy and the control group for 1181G>Cand 950T>Cpolymorphisms, and between the group of subjects with neuropathy but no Charcot neuroarthropathy and the group of patients withCharcot neuroarthropathy for 1217C>T and 245T>G polymorphisms. Conclusion: We suggest that genetic factors, particularly OPG gene polymorphisms, may play a role in the development of diabetic Charcot neuroarthropathy.
• Object availability:
  free access
• Date:
  2011
• Type:
  Article;
  PeerReviewed
• Language:
  English
• Format:
  application/msword
• Relation: http://eprints.ibb.waw.pl/249
• Subject:
  QH426 Genetics;
  R Medicine (General)
• Identifier: http://eprints.ibb.waw.pl/249/1/Charcot_pap_1_7.doc ;
  Korzon-Burakowska, Anna and Jakóbkiewicz-Banecka, Joanna and Fiedosiuk, Aleksandra and Petrova, Nina and Koblik, Teresa and Gabig-Cimińska, Magdalena and Edmonds, Michael and Małecki, Maciej and Węgrzyn, Grzegorz (2011) Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy. Diabetic Medicine, 28 . pp. 1-5.
• Data provider:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
• Can I use it?:
  seek permission
• Type:
  other