Object's details: Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
Creator:
Krwawicz, Joanna;
Arczewska, Katarzyna D;
Speina, Elzbieta;
Maciejewska, Agnieszka M.;
Grzesiuk, Elzbieta
Description:
Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escherichia coli cells, in human ones, the two BER sub-pathways are operated by different sets of proteins. In this review the selection between SP- and LP-BER and mutations in BER and end-processors genes and their contribution to bacterial mutagenesis and human diseases are considered.
Object availability:
free access
Date:
2007
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
Polskie Towarzystwo Biochemiczne
Relation: http://eprints.ibb.waw.pl/269 ;http://www.actabp.pl
Subject:
Q Science (General);
QH426 Genetics
Identifier: http://eprints.ibb.waw.pl/269/2/ABP_2007.pdf ;
Krwawicz, Joanna and Arczewska, Katarzyna D and Speina, Elzbieta and Maciejewska, Agnieszka M. and Grzesiuk, Elzbieta (2007) Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease. Acta biochimica Polonica, 54 (3). pp. 413-34. ISSN 0001-527X
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

Description

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