Object's details: ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland
Creator:
Stawczyk-Macieja, Marta;
Szczerkowska-Dobosz, Aneta;
Rębała, Krzysztof;
Gabig-Cimińska, Magdalena;
Nowicki, Roman J.;
Haraś, Agnieszka;
Cybulska, Lidia;
Kapińska, Ewa
Description:
Introduction: HLA-C*06 is a major psoriasis genetic risk marker. Recent reports have been focused on the role of different polymorphisms within genes involved in the functioning of the epidermal barrier and antigen processing in the pathogenesis of psoriasis. Data on the association between genetic variants of LCE3B_LCE3C, CSTA, ERAP1, ZAP70 and this dermatosis in the population from Eastern Europe are lacking. Aim: To compare the association between known genetic risk markers and psoriasis in a cohort of northern Polish patients with psoriasis and healthy controls. Material and methods: Based on previous studies’ results, five susceptibility loci: HLA-C, LCE3C_LCE3B, ERAP1, ZAP70 and CSTA were selected for genotyping in 148 patients with chronic plaque psoriasis and 146 healthy controls. Each patient with this disease was clinically assessed with the Psoriasis Area and Severity Index. Results: The study population showed a significant association of psoriasis and a single nucleotide polymorphism in the ERAP1 – rs26653 (p = 3.11 × 10–5) and HLA-C*06 allele (p = 1.02 × 10–11) when compared with the control group. The presence of HLA-C*06 or rs26653 G allele significantly increased the risk of psoriasis by 2.4 times or twice, respectively. Carrying rs26653 C allele considerably decreased the risk of psoriasis by 1.5 times. Conclusions: In the context of pathogenesis of psoriasis, our findings might give the evidence on disturbances in the proteolytic processing of N-terminal fragments of antigens presented via major histocompatibility complex class I to T cells.
Object availability:
free access
Date:
2018
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/1687 ;https://www.termedia.pl/Journal/Postepy_Dermatologii_i_Alergologii-7/Numer-3-2018
Subject:
Q Science (General)
Identifier: http://eprints.ibb.waw.pl/1687/1/Paper_PDIA_2018.pdf ;
Stawczyk-Macieja, Marta and Szczerkowska-Dobosz, Aneta and Rębała, Krzysztof and Gabig-Cimińska, Magdalena and Nowicki, Roman J. and Haraś, Agnieszka and Cybulska, Lidia and Kapińska, Ewa (2018) ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland. Advances in Dermatology and Allergology, XXXV (3). pp. 286-292.
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Similar objects

ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland

Date:2018

Type:other

Unbalanced sphingolipid metabolism and its implications for the pathogenesis of psoriasis

Creator:Bocheńska, Katarzyna | Gabig-Cimińska, Magdalena

Date:2020

Type:other

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Date:2021

Type:other

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents

Creator:Słomiński, Bartosz | Ryba-Stanisławowska, M | Skrzypkowska, M | Gabig-Cimińska, Magdalena | Myśliwiec, M

Date:2020

Type:other

Use of cytokine mix-, imiquimod-, and serum-induced monoculture and lipopolysaccharide- and interferon gamma-treated co-culture to establish in vitro psoriasis-like inflammation models

Creator:Bocheńska, Katarzyna | Moskot, Marta | Gabig-Cimińska, Magdalena

Date:2021

Type:other

Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders.

Creator:Moskot, Marta | Bocheńska, Katarzyna | Jakóbkiewicz-Banecka, Joanna | Banecki, Bogdan | Gabig-Cimińska, Magdalena

Date:2018

Type:other

The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy

Date:2020

Type:other

Cellular and gene expression response to the combination of genistein and kaempferol in the treatment of mucopolysaccharidosis type I

Date:2022

Type:other

Federacja Bibliotek Cyfrowych

Object's details: ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland

Description

Similar objects