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cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin

Object's details: cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin

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Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin
Creator:
Wezynfeld, Nina Ewa;
Goch, Wojciech;
Bal, Wojciech;
Frączyk, Tomasz
Description:
cis-Urocanic acid, a derivative of histidine, is one of the essential components of human skin. We found that it can bind nickel(II) ions in a pH-dependent manner, with the dissociation constant in the low millimolar range, as revealed by potentiometry, and confirmed by isothermal titration calorimetry and UV-vis spectroscopy. The binding occurs within the physiological skin pH range. Considering the fact that cis-urocanic acid is present in the human skin in concentrations as high as millimolar, this molecule may be a physiologically important player in nickel trafficking in the human organism.
Object availability:
free access
Date:
2014
Type:
Article;
PeerReviewed
Language:
English;
eng
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/775 ;http://dx.doi.org/10.1039/c3dt53194e ;doi:10.1039/c3dt53194e
Subject:
QD Chemistry;
QH301 Biology;
QP Physiology;
RL Dermatology
Identifier: http://eprints.ibb.waw.pl/775/1/cis-Urocanic_Acid_paper_rev_repository.pdf ;
Wezynfeld, Nina Ewa and Goch, Wojciech and Bal, Wojciech and Frączyk, Tomasz (2014) cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin. Dalton Transactions, 43 (8). pp. 3196-3201. ISSN 1477-9226
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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