Object's details: Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients.
Creator:
Zegarska, Jolanta;
Hryniewiecka, Ewa;
Żochowska, Dorota;
Tszyrsznic, Wlodzimierz;
Jazwiec, Radoslaw;
Borowiec, Agnieszka;
Pawłowska, Emilia;
Dadlez, Michal;
Paczek, Leszek
Description:
BACKGROUND Mycophenolic acid (MPA) prodrugs are anti-proliferative immunosuppressive agents commonly used after organ transplantation. Although they are generally well tolerated by patients, adverse effects may occur. It is postulated that MPA metabolites could also contribute to these adverse effects. MATERIAL AND METHODS The objective of this study was the assessment of concentrations of total MPA and its metabolites, phenyl glucuronide (MPAG), acyl glucuronide (AcMPAG) and glucoside (GluMPA), using liquid chromatography combined with mass spectrometry (LC/MS/MS) in two groups: kidney transplant recipients and liver transplant patients. Associations of MPA and its metabolites with adverse effects were analyzed. RESULTS The study group consisted of 211 recipients of liver or kidney transplants who received immunosuppressive therapy, including MPA prodrugs. Multivariant analysis showed a positive influence of MPA on gastroenterotoxicity in kidney transplant recipients. In liver patients, gastroenterotoxicity was associated with lower MPAG concentrations. A positive influence of AcMPAG on bacterial infections in liver transplant patients was observed. In liver transplant recipients, a positive influence of MPA and a negative influence of GluMPA levels on the PLT count were revealed. MPA and its metabolites did not influence the hemoglobin levels in both groups. There were no significant relationships among MPA, its metabolites and WBC counts. CONCLUSIONS In kidney transplant recipients, total MPA trough concentration is associated with gastroenterotoxicity and its monitoring could have important role in management of gastrointestinal complications. The quantification of AcMPAG in liver recipients receiving MPA may be helpful in avoiding bacterial infections. GluMPA seems to have a toxic effect on thrombopoiesis.
Object availability:
free access
Date:
2015
Type:
Article;
NonPeerReviewed
Language:
English
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/967 ;http://www.annalsoftransplantation.com/download/index/idArt/894954
Subject:
RC Internal medicine;
RM Therapeutics. Pharmacology
Identifier: http://eprints.ibb.waw.pl/967/1/proof.pdf ;
Zegarska, Jolanta and Hryniewiecka, Ewa and Żochowska, Dorota and Tszyrsznic, Wlodzimierz and Jazwiec, Radoslaw and Borowiec, Agnieszka and Pawłowska, Emilia and Dadlez, Michal and Paczek, Leszek (2015) Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. Annals of transplantation : quarterly of the Polish Transplantation Society, 20 . pp. 483-492. ISSN 2329-0358
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients.

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